| ID | Title | Location | Link with Photos | Link with Map |
| 2-1 | The S.C. Railroad | Aiken Located at the intersection of Laurens Street SW and Park Avenue. | Link with Photos Related: Link with Photos Related: Link with Photos |
Link
with Map Related: Link with Map |
| 2-2 | Western Terminus South Carolina Railroad | US I & US 25 at Savannah River | Link with Photos | Link with Map |
| 2-3 | Hamburg | US 1 at the Savannah River (marker missing) | Link with Photos | Link with Map |
| 2-4 | Historic Church All Saints Episcopal Church | US 278 about 2 miles below Beech Island at entrance to Redcliffe Plantation State Park | Link with Photos | Link with Map |
| 2-5 | James U. Jackson Memorial Bridge | North Augusta - Marker is on Georgia Avenue (U.S. 25) near Savannah River, on the right when traveling south | Link with Photos | Link with Map |
| 2-6 | The Martintown Road | North Augusta - Marker is on East Martintown Road (South Carolina Route 230), on the right when traveling north | Link with Photos | Link with Map |
| 2-7 | Beech Island Agricultural Club | Beech Island - Marker is on Williston Road (U.S. 278) just west of Spann Hammond Road, on the right when traveling west. | Link with Photos | Link with Map |
| 2-8 | Aiken County | Aiken – Corner of Park Avenue and Chesterfield street (Courthouse grounds / 109 Park Avenue, Aiken SC) | Link with Photos | Link with Map |
| 2-9 | Savannah Town / Fort Moore | Beech Island - Marker is on Sandbar Ferry Road (State Highway 28). | Link with Photos | Link with Map |
| 2-10 | Pascalis Plantation / Pascalina | Montmorenci - Marker is at the intersection of Charleston/Augusta Road (U.S. 78) and Old Tory Trail, on the right when traveling east on Charleston/Augusta Road. | Link with Photos | Link with Map Link with Map |
| 2-11 | Samuel Hammond | North Augusta - Marker is on Riverview Park Drive, in the median River View Park Activity Center (101 Riverview Park Dr, North Augusta, SC) | Link with Photos | Link with Map |
| 2-12 | St. Thaddeus Church | Aiken - 125 Pendleton St SW, Aiken SC | Link with Photos | Link with Map |
| 2-13 | Site of Ellenton | Marker is near Jackson - Marker is on Atomic Road (South Carolina Route 125) near Government 3, on the right when traveling south. | Link with Photos Link with Photos | Link with Map |
| 2-14 | Beech Island Baptist Church | Beech Island - Marker is on Church Road (South Carolina Route 581) west of Spann Hammond Road (South Carolina Route 1139), on the right when traveling west. | Link with Photos | Link with Map |
| 2-15 | Storm Branch Baptist Church | Clearwater, South Carolina, in Aiken County. Marker is at 153 Storm Branch Road, on the right when traveling west. | Link with Photos | Link with Map |
| 2-16 | Aiken Institute | Aiken - Marker is on Whiskey Road (State Highway 19) near Colleton Ave Southeast, on the right when traveling north. (314 Chesterfield Street South) | Link with Photos | Link with Map |
| 2-17 | Hampton Terrace Hotel | North Augusta - Marker is on Carolina Avenue north of West Arlington Heights, on the right when traveling north. (1000 block of Carolina Ave., North Augusta, SC). | Link with Photos | Link with Map |
| 2-18 | Downer Institute & School | Beech Island - Marker is on Williston Road (U.S. 278) near Hammond Road, on the left when traveling east. | Link with Photos | Link with Map |
| 2-19 | Schofield School | Aiken - 220 Sumter Street, Aiken, SC / 224 Kershaw Street Northeast, Aiken SC | Link with Photos | Link with Map |
| 2-20 | Marie Cromer Seigler House | Eureka - Marker is on Johnston Highway (State Highway 191) ¼ mile north of State Highway 19, on the right when traveling south. | Link with Photos | Link with Map |
| 2-21 | Silver Bluff Baptist Church | Jackson - Marker is at 360 Old Jackson Highway (State Highway 5), on the left when traveling north. | Link with Photos | Link with Map |
| 2-22 | Graniteville Mill | Graniteville - Marker is on Marshall Street near Canal Street, on the right when traveling east. | Link with Photos | Link with Map |
| 2-23 | Aiken | Aiken - Corner of Laurens Street and The Alley (downtown). | Link with Photos | Link with Map |
| 2-24 | Pickens - Salley House | Aiken - Rear of the University of South Carolina Aiken Campus. (471 University Parkway, Aiken SC) | Link with Photos | Link with Map |
| 2-25 | Millbrook Baptist Church | Aiken - 176 East Pine Log Road, Aiken SC | Link with Photos | Link with Map |
| 2-26 | Original Survey of Aiken | Aiken - Marker is at the intersection of Newberry Street SW and Richland Avenue West (U.S. 1), in the median on Newberry Street SW. | Link with Photos | Link with Map |
| 2-27 | Savannah River Plant | New Ellenton - Marker is on South Main Street (State Road 19) near Williston Road (U.S. 278), on the right when traveling east (intersection of S.C. Hwy. 19 and U.S. Hwy. 278 at the entrance to the plant, south of New Ellenton, SC) | Link with Photos | Link with Map |
| 2-28 | Jacksonville School | Warrenville/Langley, South Carolina. Marker is at the intersection of Huber Clay Road (State Highway 66) and Shephard Estates Drive, on the left when traveling south on Huber Clay Road. (351 Huber Clay Road) | Link with Photos | Link with Map |
| 2-29 | Aiken First Baptist Church | Aiken - Marker is on York Street Northeast (U.S. 1) near Richland Avenue (U.S. 78), on the right when traveling south. | Link with Photos | Link with Map |
| 2-30 | Graniteville Cemetery | Graniteville - Marker is on Gregg Highway (State Highway 895). Located approx. 1000 yards east of State Route 191. | Link with Photos | Link with Map |
| 2-31 | Hitchcock Woods | Aiken - Marker is on Laurens Street SW near South Boundary Avenue SW | Link with Photos | Link with Map |
| 2-32 | Aiken County Farmer's Market | Aiken - Marker is on Williamsburg Street near Richland Street SE (U.S. 78). | Link with Photos | Link with Map |
| 2-33 | North Augusta | North Augusta - Marker is on W Forest Avenue, on the right when traveling east. Between Georgia and Carolina Avenues at John C. Calhoun Park. | Link with Photos | Link with Map |
| 2-34 | Jefferson High School | Warrenville/Bath - Marker is at 170 Flint Drive (State Highway 731) west of Bryan Drive, on the right when traveling east. | Link with Photos | Link with Map |
| 2-35 | St. Johns Methodist Church | Aiken - 104 Newberry St NW, Aiken SC | Link with Photos | Link with Map |
| 2-36 | P Reactor | Road F, Savannah River Site (Not Open to the Public) | n/a | Link with Map |
| 2-37 | R Reactor | Near the intersection of Roads E & G, Savannah River Site (Not Open to the Public) | n/a | Link with Map |
| 2-38 | The Augusta & Aiken Railway | Aiken - Marker is at the intersection of Laurens St. NW and Edgefield Ave NW, in the median on Laurens St. NW. | Link with Photos | Link with Map |
| 2-39 | Whitney Park | Aiken - Marker is at the intersection of S Boundary Ave SE and Chesterfield St. S, on the right when traveling west on S Boundary Ave SE | Link with Photos | Link with Map |
| 2-40 | First Presbyterian Church of Aiken | Aiken - Marker is on Barnwell Avenue Northwest near Laurens Street, NW (State Road 19), on the right when traveling west (224 Barnwell Ave. NW, Aiken, SC). | Link with Photos | Link with Map |
| 2-41 | World War II POW Camp | Aiken - Marker is on Laurens Street North West (State Highway 19) north of Jones Avenue, on the right when traveling north. Located Between Jones Avenue and Beams Road in front of Mattie C. Hall Health Care Center at driveway. (830 Laurens St., Aiken, SC) | Link with Photos | Link with Map |
| 2-42 | Highland Park Hotel | Aiken - Marker is on Highland Park Drive near Highland Park Terrace SW. | Link with Photos | Link with Map |
| 2-43 | Wagener | Wagener - Marker is on Railroad Avenue E (South Carolina Route 39) near Park Street NE, on the right when traveling west. (Main St. N & Park St., Wagener, SC) | Link with Photos | Link with Map |
| 2-44 | The Detection of the Neutrino, 1956 | Aiken, near corner of Chesterfield Street and Richland Avenue. (121 Richland Avenue, Aiken, SC) | Link with Photos | Link with Map |
| 2-45 | Hamburg Massacre | North Augusta - U.S. Hwy. 1/78/25 at the 5th St. Bridge, North Augusta, SC Note: May not be posted. | n/a | Link with Map |
| 2-46 | Coker Spring | Spring: Aiken - Coker Springs Rd. SW Marker: Aiken, Corner of Newberry Street and South Boundary Avenue Note: The marker is located near the Aiken County Museum, about ½ mile from the Coker Spring. | Spring: Link with Photos Marker: Link with Photos | Link with Map |
| 2-47 | Aiken Hospital | Aiken - Marker is on Richland Avenue W (U.S. 1) near Morgan Street, on the right when traveling west. (828 Richland Avenue West, Aiken, SC) | Link with Photos | n/a |
| 2-48 | Camp Butler | Aiken - Marker is on Wagener Road (South Carolina Route 302 / 4) near New Holland Road, on the right when traveling west. Located at the Southwest bank of Shaw's Creek (bridge). | Link with Photos | n/a |
| 2-49 | Leavelle McCampell School | Graniteville – 82 Canal Street | n/a | n/a |
| 2-50 | Aiken Graded School | Aiken - Near 420 Hampton Avenue, Aiken, SC | n/a | n/a |
| 2-51 | Aiken Preparatory School | Aiken - 619 Barnwell Ave NW, Aiken, SC | n/a | n/a |
| 2-52 | Kalmia (Home of William Gregg) | Aiken - Corner of Gregg Avenue and Richland Avenue | n/a | n/a |
| 2-53 | Pinelawn Cemetery | Aiken - near corner of Florence Street and Hampton Ave | n/a | n/a |
| 2-54 | Graniteville Academy | Graniteville - Corner of Gregg Highway and Canal Street | n/a | n/a |
| 2-55 | Adath Yeshurun Synagogue | Aiken - 154 Greenville St NW, Aiken, SC 29802 | n/a | n/a |